Zika virus is an rising mosquito‐borne infectious
agent that's related to Guillain–Barré syndrome in adults and abnormality and
alternative medical specialty defects in newborns. Despite being declared a
global emergency by the globe Health Organization, relatively very little is
understood regarding its biology. Here, we tend to investigate the methods
utilized by the virus to suppress the host antiviral response
We tend to observe that after established, Zika viral
infection is impermeable to antiviral drug treatment suggesting that the virus
deploys effective countermeasures to host cell defences. this is often
confirmed by experiments showing that Zika viral infection impairs the
induction of type‐I antiviral drug likewise as downstream interferon‐stimulated
genes. Multiple microorganism proteins have an effect on these processes.
Virus‐mediated degradation of STAT2 acts to scale back
type‐I and type‐III interferon‐mediated communication. Further, the NS5 of Zika
virus binds to STAT2, and its expression is related to with STAT2 degradation
by the proteasome. Together, our findings give key insights into however Zika
virus blocks cellular defense systems. This successively is vital for
understanding pathologic process and will aid in coming up with antiviral therapies.
To Join in this interesting discussion, visit us in:
Conference Name: 8th European Clinical Microbiology and Immunology Congress
Date and venue: June 12-13, 2019 & Edinburgh, Scotland
Contact: Erika Madison
Office Phone: 44 203 769 1755 [Mention
Helen/ Erika Madison]
LinkedIn: Erika Madison
Twitter: @MicrobioEvents
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