Receptor binding has been shown to influence host susceptibleness
to the toxins. Despite this significant role for ANTXR within the outcome of
sickness, and therefore the reportable immunomodulatory consequence of the
anthrax toxins throughout infection, very little is understood regarding ANTXR
expression on human leucocytes.
we tend to characterised the expression levels of ANTXR1
(TEM8) on human leucocytes mistreatment flow cytometry. so as to assess the
result of previous poison exposure on ANTXR1 expression levels, leucocytes from
people with no notable exposure, those exposed to poison through vaccination
and convalescent people were analysed. Donors can be outlined as either ‘low’
or ‘high’ expressers supported the proportion of ANTXR1‐positive monocytes
detected.
Previous exposure to toxins seems to modulate ANTXR1
expression, exposure through active infection being related to lower receptor
expression. a major correlation between low receptor expression and high
anthrax toxin‐specific antiviral (IFN)‐γ responses was determined in
antecedently infected people. we tend to propose that there's associate
attenuation of ANTXR1 expression post‐infection which can be a protecting
mechanism that has evolved to stop reinfection.
To Learn More: Join us in the Discussion: 8th European
Clinical Microbiology and Immunology Congress on June 12-13, 2019, Edinburgh,
Scotland
Contact: Erika Madison
Office Phone: 44 203 769 1755 [Mention
Helen/ Erika Madison]
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