The etiology of skin condition could be a complicated
method, and skin condition is one in all the foremost common skin disorders
touching immeasurable folks. The pathologic process of skin condition is
closely related to the microorganism, Propionibacterium acnes that was
antecedently called eubacterium parvum.
Each viable and non‐viable P. acnes/C. parvum are
shown to induce Associate in Nursing immunostimulatory result in vivo,
suggesting that even dead bacterium still activate Associate in Nursing
inflammatory response. skin condition treatments with lasers or devices, induce
a germicidal result through heat generation which can not address the
immunogenic activity of P. skin conditions and also the ensuing acne
inflammation.
Therefore, we tend to sought-after to see whether or
not killed P. skin conditions is capable of causing Associate in Nursing
inflammatory response and thus can be a contributory think about acne. Direct
heat treatment of P. acnes cultures with temperatures starting from 50°C to
80°C reduced P. acnes viability. each viable and heat‐killed P. acnes activated
the p38 MAP enzyme and its downstream substrate Hsp27.
Stimulating keratinocytes with traditional and
heat‐inactivated P. acnes resulted in Associate in Nursing induction of
pro-inflammatory gas and IL‐8 production. therefore killed P. skin conditions
is capable of causing inflammation in skin suggesting that therapies that have
each germicidal and anti‐inflammatory effects could end in a simpler treatment
of patients with acne than treatments that square measure germicidal alone.
To Learn More: Join us in the Discussion: Clinical Microbiology 2019
Contact Name: Erika Madison
Office Phone: 44 203 769 1755
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